This paper describes the comparison between two drug control strategies to hemophilia A. To emulate blood clotting and the pathological condition of hemophilia, a mathematical model composed by 14 ordinary differential equations is considered. We adopt a variable structure non-linear PID approach and a Model Predictive Control in order to control the dosage of procoagulant factor used in the treatment of hemophiliac patient. The two control actions are sampled for a practical application. Finally, we discuss and compare the results of the two control approaches, introducing a suited control index (eINR).
Procoagulant control strategies for the human blood clotting process / Laurino, M; Menara, T; Stella, A; Betta, Monica; Landi, M. - Volume 2015-November:(2015), pp. 7319380.4439-7319380.4442. ( 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 MiCo Center, Milano Congressi Center, ita 2015) [10.1109/EMBC.2015.7319380].
Procoagulant control strategies for the human blood clotting process
BETTA, MONICA;
2015
Abstract
This paper describes the comparison between two drug control strategies to hemophilia A. To emulate blood clotting and the pathological condition of hemophilia, a mathematical model composed by 14 ordinary differential equations is considered. We adopt a variable structure non-linear PID approach and a Model Predictive Control in order to control the dosage of procoagulant factor used in the treatment of hemophiliac patient. The two control actions are sampled for a practical application. Finally, we discuss and compare the results of the two control approaches, introducing a suited control index (eINR).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
