A 3-D porous apatite scaffold (B-HA), recently obtained through biomorphic transformation of a natural wood, is investigated on its multi-scale porous structure determining superior biological and mechanical behaviour. B-HA shows a hierarchically organized architecture with wide aligned channels interconnected with smaller tubules, thus recapitulating in detail the lymphatic network of the original wood template. As induced by its biomimetic architecture, B-HA displays values of tensile/compressive strengths and stiffness, higher than values usually measured in sintered ceramics with isotropic porosity. Furthermore, B-HA shows uncommon toughness for a pure ceramic body, plus a tensile/compressive-strength ratio higher than one, so that the material occupies a zone in the Ashby map where ceramics are normally absent. From biological viewpoint, cell co-culture tests in bioreactor are shown to report encouraging results in enhancing the complex tissue regeneration process, thus making B-HA promising as a scaffold able to promote bone regeneration, particularly for large bone defects.

Hierarchical porosity inherited by natural sources affects the mechanical and biological behaviour of bone scaffolds

Marco Paggi;
2020

Abstract

A 3-D porous apatite scaffold (B-HA), recently obtained through biomorphic transformation of a natural wood, is investigated on its multi-scale porous structure determining superior biological and mechanical behaviour. B-HA shows a hierarchically organized architecture with wide aligned channels interconnected with smaller tubules, thus recapitulating in detail the lymphatic network of the original wood template. As induced by its biomimetic architecture, B-HA displays values of tensile/compressive strengths and stiffness, higher than values usually measured in sintered ceramics with isotropic porosity. Furthermore, B-HA shows uncommon toughness for a pure ceramic body, plus a tensile/compressive-strength ratio higher than one, so that the material occupies a zone in the Ashby map where ceramics are normally absent. From biological viewpoint, cell co-culture tests in bioreactor are shown to report encouraging results in enhancing the complex tissue regeneration process, thus making B-HA promising as a scaffold able to promote bone regeneration, particularly for large bone defects.
Biomorphic ceramic
Multi-scale hierarchical pore structure
Mechanical properties
Ductility
Cell co-culture
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11771/17260
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